Endocrine Abstracts

Aim of the study: The objectives of this study were to determine the regulation of glycemia (measured by fasting glucose levels and HbA1c) in patients with type 2 diabetes and to examine whether there is a difference in therapy (oral antidiabetics, insulin, combination), age, sex and BMI.Study design: Cross-sectional research with historical data.Patients: The study included 102 patients of both sexes (56% women and 44% men) with a...

Introduction: The role of metformin in PCOS is very well known and several studies reported effects of thiazolidinediones and SGLT2 inhibitors on metabolic parametars in these patients.Objective: The aim of this study was to compare the effects of metformin, pioglitazone and empagliflozin treatment on metabolic control, hormonal imbalance, weight loss and ovulations in obese patients with PCOS and prediabetes.Methods: BMI, waist ci...

Background: Type 1 diabetes mellitus (T1DM) is caused by destruction of pancreatic beta cells. Children and adolescents with type 1 diabetes have an increased risk of developing other autoimmune diseases, most commonly autoimmune thyroiditis and celiac disease.Objectives: To examine the frequency of individual human leukocyte antigen (HLA) alleles in people with T1DM and associated autoimmune (AI) diseases of the thyroid, digestive system, and skin, and ...

Aim of the Study: The main objectives were to examine the incidence of hyperlipoproteinemia in postmenopausal women and to determine the differences in lipid profile considering age, duration of menopause and body mass index in postmenopausal women.Material and Methods: The research was structured as a cross-sectional research with historical data. The research used data collected during regular check-ups in primary health care clinics in the Osijek Heal...

Introduction: Paraganglioma is a tumour derived from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of the thorax, abdomen and pelvis. About 36 % to 60 % of the paragangliomas are functional secreting norepinephrine and normetanephrine, which cause hypertension. Non-functional paragangliomas can produce Chromogranin A. Paragangliomas also arise from the parasympathetic ganglia located along the glossopharyngeal and vagal nerves in the neck and at the b...

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder characterised by the appearance of multiple, mostly benign, tumours throughout the skin and central nervous system. Furthermore, NF1 is associated with a number of (pre)malignant tumours including pheochromocytoma, glioma, invasive breast cancer and (pre)malignant peripheral nerve sheath tumours (1). Approximately 1:2500 to 1:3500 individuals are affected.Medull...

Background and Aims: Individuals with Down syndrome have an increased risk of developing hypothyroidism, autoimmune etiology. Prevalence of hypothyroidism in Down syndrome people is from 15% to 65%. Congenital hypothyroidism is about 25 times more common among newborns and infants with Down syndrome in comparison with the general population with incidence of 0.7% permanent cases and 0.3% transient congenital hypothyroidism cases, detected by newborn screening. Beyond the newbo...

Introduction: Pancreatic neuroendocrine tumors (panNETs) are often inoperable at diagnosis. The mTORC1 inhibitor everolimus is approved for the treatment of advanced NETs. Unfortunately, the development of resistance against everolimus limits its clinical efficacy.Aim: Our aim was to establish an everolimus-resistant panNET cell line to find common mechanisms of resistance.Methods: Pancreatic neuroendocrine tumor cells (BON1) were ...

Background: Patients with heterozygote germline mutations in the aryl-hydrocarbon receptor interacting protein (AIP) gene (AIPpos) develop often aggressively growing tumours in early teenage years. The mechanism of this behaviour is not clear.Aim: The role of the microenvironment in the invasive phenotype of AIPpos pituitary tumours.Methods and results: We established that AIPpos GH-secreting tumours are infiltrated by a large numb...

Cyclin-dependent kinases (CDKs) are crucial for the cell cycle regulation and alterations of the cell cycle and its regulators are often observed in human malignancies. CDK4/6 in particular orchestrates the G1 phase progression and the G1/S transition. Here we investigated the in vitro effects of the CDK4/6 inhibitor LEE001(Novartis, Basel) on the human neuroendocrine tumor (NET) cell lines BON1, QGP1 and NCI-H727. The cells were treated with different concentrations ...